Chronic pain
STUDY
Carter et al. (2014). Re-branding cannabis: the next generation of chronic pain medicine? Pain Management, 5(1), 13-21.
STUDY DESIGN
Metaanalysis/Review
INVESTIGATIONAL PRODUCT
Cannabis blossoms
RESULTS
Evidence of therapeutic options in chronic pain patients with cannabis or cannabis as a supplement to low opiate dose.
STUDY
Romero-Sandoval et al. (2017). Cannabis and Cannabinoids for Chronic Pain. Current Rheumatology Reports, 19(11), 67.
STUDY DESIGN
Metaanalysis/Review
INVESTIGATIONAL PRODUCT
Cannabis blossoms
RESULTS
– Inhaled cannabis is better tolerated
– Application can be better controlled pulmonarily than orally administered cannabinoids
– Inhaled cannabis blossoms lead to a decrease in non-tumor pain
STUDY
Bellnier et al. (2018). Preliminary evaluation of the efficacy, safety, and costs associated with the treatment of chronic pain with medical cannabis. Mental Health Clinician, 8(3), 110-115.
STUDY DESIGN
Mirror-Image study (retrospective), N=29
INVESTIGATIONAL PRODUCT
Cannabis blossoms
RESULTS
– Medical cannabis improves quality of life
– Decrease of chronic pain and associated opiate intake
Neuropathic pain
STUDY
Wilsey et al. (2013). Lowdose vaporized cannabis significantly improves neuropathic pain. The Journal of Pain, 14(2), 136-148.
STUDY DESIGN
Cross-Over study (placebo-controlled, double-blind), N=39
INVESTIGATIONAL PRODUCT
Cannabis blossoms
RESULTS
– Significant pain reduction compared to placebo subjekts
– Low side effects due to cannabis-based therapy
STUDY
Eisenberg et al. (2014). The Pharmacokinetics, Efficacy, Safety, and Ease of Use of a Novel Portable Metered-Dose Cannabis Inhaler in Patients With Chronic Neuropathic Pain: A Phase 1a Study. Journal of Pain and Palliative Care Pharmacotherapy, 23(3), 216-225.
STUDY DESIGN
Phase-I-study, N=8
INVESTIGATIONAL PRODUCT
Cannabis blossoms
RESULTS
– Significant reduction of pain intensy
– Measured using visual analogue scale (VAS scale)
STUDY
Nugent et al. (2017). The Effects of Cannabis Among Adults with Chronic Pain and an Overview of General Harms: A Systematic Review. Ann Intern Med, 167, 319-331.
STUDY DESIGN
Metaanalysis/Review
INVESTIGATION PRODUCT
Cannabis blossoms
RESULTS
Cannabinoids can effectively relieve neuropathic pain.
STUDY
Lee et al. (2018). Medical Cannabis for Neuropathic Pain. Current Pain and Headache Reports, 22(1), 8.
STUDY DESIGN
Metaanalysis/Review of randomized and controlled studies, N=234
v
INVESTIGATIONAL PRODUCT
Cannabis extracts (inhaled)
RESULTS
Effective reduction of pain through cannabis-based therapy.
HIV-associated sensory neuropathy
STUDY
Abrams et al. (2007). Cannabis in painful HIV-associated sensory neuropathy A randomized placebo-controlled trial. Neurology, 68(7), 515-521.
STUDY
Randomized, placebo-controlled study (prospective), N=50
INVESTIGATIONAL PRODUCT
Cannabis blossoms
RESULTS
The cannabis therapy could reduce the pain sensation by 30% compared to the control group with placebo.
Palliative Oncology
STUDY
Johnson et al. (2010). Multicenter, doubleblind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain. J Pain Symptom Manage, 39:167-179.
STUDY DESIGN
Parallel group study (randomized, double-blind, placebo-controlled), N=177
INVESTIGATIONAL PRODUCT
Drugs containing cannabis
RESULTS
The cannabis therapy was able to significantly reduce the pain in cancer patients. In particular, patients who cannot be sufficiently painlessly treated with opioids benefit from additional medication with cannabinoids.
STUDY
Bar-Sela et al. (2013). The medical necessity for medicinal cannabis: prospective, observational study evaluating treatment in cancer patients on supportive or palliative care. Evidence-Based Complementary and Alternative Medicine, 510392.
STUDY DESIGN
Observational study (prospective), N=131
INVESTIGATIONAL PRODUCT
Cannabis blossoms
RESULTS
The cannabis therapy could significantly reduce the symptoms (CTAE scale).
STUDY
Waissengrin et al. (2015). Patterns of use of medical cannabis among Israeli cancer patients: a single institution experience. Journal of Pain and Symptom Management, 49(2), 223-230.
STUDY DESIGN
Observational study, N=69
INVESTIGATIONAL PRODUCT
Cannabis blossoms
RESULTS
The cannabis therapy could:
– reduce pain
– improve general well-being
– relieve nausea
– stimulate appetite
Nausea and vomiting during chemotherapy
STUDY
Sallan SE, Zinberg NE, Frei E. (1975). Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy. New England Journal of Medicine, 293(16), 795-797.
STUDY DESIGN
Cross-over study (randomized, double-blind, placebo-kontrolled), N=20
INVESTIGATIONAL PRODUCT
Cannabis-based drugs
RESULTS
Antiemetic effect in subjects with cannabis compared to placebo.
STUDY
Duran et al. (2010). Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting. British Journal of Clinical Pharmacology, 70(5), 656-663.
STUDY DESIGN
Phase-II-study (randomized, double-blind, placebo-controlled), N=7
INVESTIGATIONAL PRODUCT
Cannabis extract, CBD
RESULTS
The cannabis therapy increases the antiemetic effect of the standard therapy compared to the placebo.
Anorexia and cachexia: HIV/AIDS associated
STUDY
Beal et al. (1995). Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS. Journal of pain and symptom management, 10(2), 89-97.
STUDY DESIGN
Parallel group study (randomizes, double-blind, placebo-controlled), N=139
INVESTIGATIONAL PRODUCT
Dronabinol/THC (oral)
RESULTS
– increase in appetite
– Reduction of nausea
– Twice as much weight gain was observed compared to pkacebo
STUDY
Haney et al. (2007). Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep. JAIDS Journal Acquired Immune Deficiency Syndromes 45(5), 545-554.
STUDY DESIGN
Within-Subject study (randomized, placebo-controlled), N=10
INVESTIGATIONAL PRODUCT
Cannabis blossoms and Dronabinol
RESULTS
Cannabis therapy leads to increased calorie intake.
Anorexia and Cachexia: In Chemotherapy
STUDY
Regelson et al. (1976). Delta-9-tetrahydrocannabinol as an effective antidepressant and appetite-stimulating agent in advanced cancer patients. Pharmacology of Marihuana, 2, 763-776.
STUDY DESIGN
Cross-over study (randomized, double-blind, placebo-controlled), N=10
INVESTIGATIONAL PRODUCT
THC (oral)
v
RESULTS
Cannabis therapy led to increased appetite.
STUDY
Whiting et al. (2015). Cannabinoids for Medical Use: A Systematic Review and Meta-analysis. JAMA, 313:2456-2473.
STUDY DESIGN
Meta-analysis/review from 34 Studies
INVESTIGATIONAL PRODUCT
Cannabis blossoms and cannabis extract
RESULTS
Cannabis therapy led to:
– Reduction of central nervous pain in MS
– Reduction of pain caused by spasticity
Spasticity in multiple sclerosis
STUDY
Collin et al. (2010). A doubleblind, randomized, placebocontrolled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis. Neurological Research, 32(5), 451-459.
STUDY DESIGN
Between-Subject study (placebo-controlled, double-blind), N=337
INVESTIGATIONAL PRODUCT
Cannabis extract
RESULTS
Reduction of therapy-resistant spasticity.
STUDY
Corey-Bloom et al. (2012). Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial. Canadian Medical Association Journal, 184(10), 1143-1150.
STUDY DESIGN
Cross-Over study (placebo-controlled), N=30
INVESTIGATIONAL PRODUCT
Cannabis blossoms
RESULTS
Therapy with cannabis blossoms led to reduction of spasticity, pain and exhaustion.
STUDY
Nielsen et al. (2018). The Use of Cannabis and Cannabinoids in Treating Symptoms of Multiple Sclerosis: A Systematic Review of Reviews. Current Neurology and Neuroscience Reports, 18(2), 8.
STUDY DESIGN
Metaanalysis/review from 32 Studien
INVESTIGATIONAL PRODUCT
Cannabis-based drugs
RESULTS
Evidence for reduction of pain and spasticity in multiple sclerosis.
Central nervous pain in multiple sclerosis
STUDY
Whiting et al. (2015). Cannabinoids for Medical Use: A Systematic Review and Meta-analysis. JAMA, 313:2456-2473.
STUDY DESIGN
Metaanalysis/review from 34 Studien
INVESTIGATIONAL PRODUCT
Cannabis blossoms and cannabis extract
RESULTS
Cannabis therapy led to:
– Reduction of central nervous pain in multiple sclerosis
– Reduction of pain caused by spasticity
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